|
KMID : 0358420080510050518
|
|
Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 5 p.518 ~ p.526
|
|
|
The expression of Thymosin β4 with angiogenic factors in epithelial ovarian cancer
|
|
Kim A-Ri
Kim Jong-Il
Moon Hye-Sung
Chung Hye-Won
Chun Sun-Hee
|
|
|
Abstract
|
|
|
Objective: The aim of this study was to determine thymosin β4 expression in epithelial ovarian cancer compared to normal ovarian tissue.
Methods: Normal and pathologic ovarian tissues were obtained from healthy women (n=18), and from patients with ovarian cancer (n=27). The expression of thymosin β4 mRNA was examined by quantitative competitive polymerase chain reaction (QC PCR). Thymosin β4 mRNA expression was examined with angiopoietic factors such as vascular endothelial growth factor, angiopoietin-1 and 2.
Results: The expression of thymosin β4 mRNA in epithelial ovarian cancer was higher than that in the normal ovary (p<0.05). Thymosin β4 mRNA expression was not correlated with ovarian cancer stages, pathologic types, preoperative CA125 levels, or metastasis to lymph nodes but was correlated with the expression vascular endothelial growth factor and angiopoietin-2 (p<0.05).
Conclusions: Our results suggest that overexpression of thymosin β4 mRNA may be a biologic marker to differentiate epithelial ovarian cancer from normal ovary and it may play a role in angiogenesis of epithelial ovarian cancer.
|
|
|
KEYWORD
|
|
|
Thymosin β4, Ovarian cancer, Angiogenesis
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|